| Powder: | Yes |
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| Certification: | ISO 9001, COA,FDA |
| Purity: | >98% |
| CAS: | 70288-86-7 |
| Sample: | Feel Free to Contact Us. |
| OEM Service: | Acceptable |
| Customization: |
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Audited Supplier | Product name | Ivermectin | CAS No. | 70288-86-7 |
| Appearance | White crystalline powder | Specification | 98%HPLC |
| Application | Pharmaceutical industry | ||
| Ivermectin is a white crystalline powder; it is tasteless. This product is easily soluble in ethanol, almost insoluble in water, slightly hygroscopic. Ivermectin is a sixteen-membered ring of macrolide antibiotics. Its basic structure is a large ester ring on the 16-carbon position and three main substituent groups, namely the hexahydrophenylpropene on the C2 to C8 positions. Furans, disaccharide groups at the C13 position, ketone groups at the C17 to C18 positions. Ivermectin is a new type of high-efficiency semi-synthetic antibiotic insecticide, acaricide and nematicide. It is an insect nerve agent and biological penetrant. The mechanism of action is to interfere with the neurophysiological activities of pests, stimulate the release of γ-aminobutyric acid, act on the nerve and muscle junctions, increase the release of chloride ions, and inhibit the information transmission of the nerve junctions, resulting in paralysis and death of pests and mites. Its product is colorless or light brownish yellow liquid. Ivermectin is a new type of broad-spectrum, high-efficiency, low-toxicity antibiotic antiparasitic drug, which has a good repellent effect on parasites inside and outside the body, especially nematodes and arthropods. But it has no effect on tapeworms, flukes and protozoa. The repellent effect of macrolide antiparasitic drugs on nematodes and arthropods is to increase the release of the inhibitory transmitter γ-aminobutyric acid (GABA) and to open the Cl ion channel controlled by glutamate. Enhance the permeability of the nerve membrane to Cl, thereby blocking the transmission of nerve signals, and ultimately nerve paralysis, causing muscle cells to lose the ability to contract, which leads to the death of the worm. The different adjuvants contained in commercial ivermectin preparations can affect the effect of the drug. For example, when the dosage of ivermectin reaches 4000μg/kg, it is still safe when the preparation containing Tween-80 as an adjuvant is taken orally in sheep. |
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