| Customization: | Available |
|---|---|
| Certification: | FDA, HACCP, HACCP Sc SGS, ISO 9001, FDA, COA |
| Assay Method: | HPLC, UV |
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| Product name | Diindolylmethane /DIM | CAS No. | 1968-05-4 |
| Appearance | White powder | Specification | 99%HPLC |
| 3,3'-Diindolylmethane is widely found in natural plants of the cruciferous family. It has important biological and pharmacological activities and is widely used in the fields of medicine and health products. DIM is an effective radiation shield and mitigator, which works by stimulating ATM-driven DDR-like responses and NF-κB survival signals. DIM can inhibit tumor cell invasion, angiogenesis, proliferation and induce apoptosis by regulating signal pathways, such as AKT, NF-κB and FOXO3. It can also inhibit gene expression induced by estrogen and cause endoplasmic reticulum stress response. DIM can change the metabolism of estrogen and antagonize the activity of estrogen and androgen receptors. Application: Pharmaceutical intermediate; has the function of an anti-tumor agent; this derivative, under relatively high concentration conditions, can not only directly accelerate the apoptosis of human cancer cells, but also sensitize TRAIL to induce apoptosis of human cancer cells; DIM induces a G1 Cell loop inhibition, expressed in human breast cancer MCF-7 cells through mechanism and inclusion; DIM is a potent inhibitor of mitochondrial H+-ATPase; as a new plant growth promoter, DIM and its derivatives have functioned Used in eco-friendly system research. |
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